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Otolaryngology-Head and Neck Surgery

Machine Biointerface Lab: Overview

Dr. Fridman的研究小组发明和开发用于神经工程和医疗仪器应用的生物电子学. 我们开发创新的医疗技术，我们也进行必要的生物学研究，以了解该技术如何对人们有效和安全.

我们的实验室目前专注于开发“安全直流刺激”技术，简称SDCS. 不同于目前市面上的神经修复装置, such as cochlear implants, pacemakers, 或者帕金森氏症深部脑刺激器，只能刺激神经元, SDCS can excite, inhibit, and even sensitize them to input. 这项新技术为我们目前正在探索的设备开发的广泛应用打开了一扇门.g. 外周神经刺激抑制神经性疼痛, 刺激前庭神经纠正平衡障碍, vagal nerve stimulation to suppress an asthma attack, and a host of other neuroprosthetic applications.

M口腔实验室是我们在机器生物接口实验室发明的一种“三录仪”设备. 该设备目前可获得60秒内的所有生命体征:脉搏率, breathing rate, temperature, blood pressure, blood oxygen saturation, electrocardiogram, and FEV1 (lung function) measurement. Because the device is in the mouth, 它可以进入唾液和呼吸，我们现在专注于扩大它的能力，以获得脱水和生物标志物的测量，这些生物标志物可以指示各种内部疾病，从压力到肾衰竭，甚至肺癌.

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Latest Research

See the latest research from this lab in PubMed and Google Scholar.

Principal Investigator

Gene Y. Fridman, PhD

  • 耳鼻喉头颈外科副教授

Collaborators

Lab Members

  • Kelly Lane
  • Felix Aplin
  • Raviraj Thakur
  • Dilawer Singh
  • Golnoosh Kamali
  • Ankitha Rajagopalan Nair
  • Chojun Cheng

Publications

  • Chang AD, Berges VA, Chung SJ, friedman GY, Baraban JM, Reti IM.  高频刺激丘脑底核抑制自闭症样小鼠模型过度自我梳理. Neuropsychopharmacology. 2015 Nov 26. doi: 10.1038/npp.2015.350. [Epub ahead of print]  PMID: 26606849
  • Fridman GY, Tang H, Feller-Kopman D, Hong Y. 口腔实验室:为快速医疗评估优化的三录仪概念. Ann Biomed Eng. 2015 Sep;43(9):2175-84. doi: 10.1007/s10439-015-1247-1. Epub 2015 Jan 21. PubMed PMID: 25605586.
  • Hageman KN, Kalayjian ZK, Tejada F, Chiang B, Rahman MA, Fridman GY, Dai C, Pouliquen PO, Georgiou J, Della Santina CC, Andreou AG. 用于多通道前庭假体的CMOS神经接口. IEEE Trans Biomed Circuits Syst. 2015 May 11. [Epub ahead of print] PubMed PMID: 25974945.
  • Fridman GY, Della Santina CC.、安全直流刺激器2:概念与设计. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:3126-9. doi: 10.1109/EMBC.2013.6610203  PMID: 24110390
  • Valentin NS, Hageman K, Dai C, Della Santina CC,  Fridman GY, 通过对市售人工耳蜗的改良，开发多通道前庭假体原型, IEEE Trans Neural Syst Rehabil Eng. 2013 May 1. [Epub ahead of print] PubMed PMID: 23649285
  • Fridman GY, Della Santina CC, 安全的直流电刺激扩展神经假体的功能, IEEE Trans Neural Syst Rehabil Eng. 2013 May 1. PubMed PMID: 23649285
  • Davidovics NS, Rahman MA, Dai C, Ahn JH, Fridman GY, Della Santina CC, 多通道前庭假体采用脉冲速率和电流调制与对准预补偿，可改善猴子的VOR功能, J Assoc Res Otolaryngol. 2013 Apr;14(2):233-48. doi: 10.1007/s10162-013-0370-7. Epub 2013 Jan 26. PubMed PMID: 23355001; PubMed Central PMCID: PMC3660911
  • Fridman GY, Della Santina CC., 治疗双侧前庭功能缺损的多通道前庭假体研究进展.”, Anat Rec (Hoboken). 2012 Nov;295(11):2010-29. doi: 10.1002/ar.22581. Epub 2012 Oct 8
  • Davidovics NS, Fridman GY, Della Santina CC., “刺激率和高基线电流的共同调节扩大了前庭假体的头部运动编码范围.”, Exp Brain Res. 2012 May;218(3):389-400. doi: 10.1007/s00221-012-3025-8. Epub 2012 Feb 19.
  • Sun D.Q., Rahman MA, Fridman GY, Chiang B, Dai C, Della Santina CC, 使用多通道前庭假体慢性刺激半规管:对龙猫运动和角前庭-眼反射的影响, Conf. Proc. IEEE 33rd Annual EMBC Conference, Boston, MA 2011
  • Rahman MA, Dai C, Fridman GY, Davidovics NS, Chiang B, Ahn JH, Hayden R, Melvin TN, Sun DQ, and Della Santina CC, “通过电刺激恢复3D前庭-眼反射:约翰霍普金斯多通道前庭假体项目. Proc. IEEE 33rd Annual EMBC Conference, Boston, MA 2011 
  • Dai, C, Fridman GY, Chiang B, Davidovics NS, Melvin TA, Cullen KE, Della Santina CC, “通过头戴式多通道前庭假体在慢性刺激下改善3D前庭-眼反射对齐”, Exp Brain Res. 2011 May;210(3-4):595-606. Epub 2011 Mar 4.
  • Chiang B, Fridman G, Dai C, Della Santina C, 多通道前庭假体的设计和性能，恢复猕猴半规管感觉.”,  IEEE Trans Neural Syst Rehabil Eng. 2011 Oct;19(5):588-98. Epub 2011 Aug 18.
  • Dai C, Fridman GY, Della Santina CC. 前庭假体电极植入和刺激对猕猴听力的影响, Hear Res. 2011 Jul;277(1-2):204-10. Epub 2010 Dec 31.
  • Della Santina CC, Migliaccio AA, Hayden R, Melvin TA, Fridman GY, Chiang B, Davidovics NS, Dai C, Carey JP, Minor LB, Anderson ICW, Park H, Lyford-Pike S, Tang S,  双侧前庭感觉丧失的当前和未来管理——约翰霍普金斯多通道前庭假体项目的最新进展,耳蜗植入国际2010年9月11日(s2): 2-11.
  • Davidovics NS, Fridman GY, Chiang B, Della Santina CC, “Effects of biphasic current pulse frequency, amplitude, 假体前庭神经电刺激下眼动反应的持续时间和间期间隙, IEEE Trans Neural Syst Rehabil Eng. 2011 Feb;19(1):84-94. Epub 2010 Sep 2.
  • Fridman GY., Davidovics NS, Dai CC, Migliaccio AA, Della Santina CC，《推荐十大正规网赌平台》, J Assoc Res Otolaryngol. 2010 Sep;11(3):367-81. Epub 2010 Feb 23.
  • Fridman GY, Blair HT, Blaisdell AP,  Judy JW. “体感皮层电刺激的感知强度”，Exp Brain Res. 2010 Jun; 203(3):499-515.
  • Jacobs AL, Fridman GY, Douglas RM, Alam NJ, Latham PE, Prusky GT, Nirenberg S, (2009) “Ruling Out and Ruling in Neural Codes”, 国家科学院学报106(14):5936-5941 4月7日, 2009
  • Litvak LM, Spahr AJ, Saoji AA, Fridman GY, (2007)“人工耳蜗和声码器听者的频谱纹波感知与语音识别的关系”, 声学学报22 (2):982-991,2007
  • Fridman GY, Blair HT, Blaisdell AP, Judy JW, 体感反馈改善脑机接口:大鼠须桶体感皮层的刺激研究, 2007第三届国际IEEE/EMBS神经工程会议, Vols 1 and 2  Pages: 379-385 

Funding

Learn more about the Machine Biointerface Lab’s funding.